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Possibility of the reversal of multidrug resistance and the avoidance of side effects by liposomes modified with MRK-16, a monoclonal antibody to P-glycoprotein

✍ Scribed by Hirotami Matsuo; Masahiro Wakasugi; Hitomi Takanaga; Hisakazu Ohtani; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada

Book ID: 114161395
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 451 KB
Volume: 77
Category: Article
ISSN: 0168-3659
DOI: 10.1016/s0168-3659(01)00460-6

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SDZ PSC833 (PSC833). an analogue of cyclosporines, is one of the most potent modulators of multi-drug resistance (MDR). We previously reported that MRK-16, an anti-P-glycoprotein MAC. enhanced MDR reversal activity of cyclosporin A (CsA) through inhibition of P-glycoprotein-mediated CrA transport. W