Possibilities of collagen adsorption on some polymeric matrices based on styrene copolymers

✍ Scribed by Loredana Elena Nita; Aurica P. Chiriac; Cornelia Vasile

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 195 KB
• Volume: 100
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.22836

✦ Synopsis

Abstract

Seven matrices based on polystyrene and styrene copolymers, with acrylic and methacrylic acid, acryl‐ and methacrylamide, and acrylonitrile and maleic anhydride, are tested in respect of their capacity of collagen adsorption. The aim of the study is to correlate the collagen coupling capacity by the nature of the monomers and the ability of functional groups to obtain biomaterials. The prepared vinylic polymers are relatively hydrophobic. These hydrophobic properties, together with the large mesh interstices, hinder smooth‐cell seeding. In contrast, collagen offers the advantage of specific cell interactions and hydrophilicity. Therefore, synthetic polymers and collagen have been hybridized to combine their advantages. The biocompatibilization process consists of physical immobilization of the protein onto the synthesized matrice surfaces. The content of the adsorbed protein was correlated with the conditions of capture, solution pH, and sorption temperature, respectively. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 3554–3561, 2006