Positron tomographic assessment of androgen receptors in prostatic carcinoma
β Scribed by Farrokh Dehdashti; Joel Picus; Jeff M. Michalski; Carmen S. Dence; Barry A. Siegel; John A. Katzenellenbogen; Michael J. Welch
- Book ID
- 105962510
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 166 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0340-6997
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## Abstract Androgen receptor (__AR__) is a ligandβdependent transcription factor, which plays a significant role in prostate carcinogenesis. Blockade of __AR__ and its ligand, androgen is the basis for the treatment of prostate cancer (PCa). Nevertheless, a modest increase in the critical levels o
## BACKGROUND. Endocrine therapy for prostate cancer aims to reduce the levels of circulating androgen or to inhibit androgen action by blocking the androgen receptor in the prostate, or both. Studies in various animal and human prostate cancer models suggested that there may be a downregulation o
## Background: We investigated modulation of androgen receptor (ar) activity in prostatic tumor cells by luteinizing hormone-releasing hormone (lhrh)-induced increase of the intracellular cyclic adenosine monophosphate (camp) level. ## Methods: Ar transactivation activity was assessed in transien