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Positron emission tomographic studies of dopa-responsive dystonia and early-onset idiopathic parkinsonism

✍ Scribed by Dr. Barry J. Snow; Torbjoern G. Nygaard; Hirohide Takahashi; Donald B. Calne


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
558 KB
Volume
34
Category
Article
ISSN
0364-5134

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We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [ 123 I]-N--fluoropropyl-2␀-carbomethoxy-3␀-(4iodophenyl) nortropane ( 123 I-FP-CIT) binding ratios indicative of Parkinson'