Positive sharp wave and fibrillation potential modeling

✍ Scribed by Daniel Dumitru; John C. King; William E. Rogers; Dick F. Stegeman

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 232 KB
• Volume: 22
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199902)22:2<242::aid-mus12>3.0.co;2-j

✦ Synopsis

A finite muscle fiber simulation program which calculates the extracellular potential for any given intracellular action potential (IAP) was used to model a fibrillation potential and a positive sharp wave. This computer model employs the core conductor model assumptions for an active muscle fiber and allows two distinct types of end effects: a cut or a crush. A "cut end" is defined as a membrane segment with the termination of both active and passive ion channels. The "crush end" is simulated as a focal membrane segment which blocks action potential propagation, and is connected to a region of normal membrane on either side of it so that a normal transmembrane potential is maintained beyond the crush zone. A prototypical positive sharp wave of appropriate amplitude and duration could only be detected extracellularly by using an IAP of the configuration found in denervated rat muscle recorded from a muscle fiber terminating in a crush segment of membrane.