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Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

✍ Scribed by Jeffrey, Kate L; Brummer, Tilman; Rolph, Michael S; Liu, Sue M; Callejas, Nuria A; Grumont, Raelene J; Gillieron, Corine; Mackay, Fabienne; Grey, Shane; Camps, Montserrat

Book ID
109923218
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
601 KB
Volume
7
Category
Article
ISSN
1529-2908

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Modulation of the phagocyte protein tyrosine phosphatase (PTP) SHP-1 by the parasite Leishmania favors its survival and propagation within its mammalian host. In vivo, the absence of SHP-1 leads to virtually absent footpad swelling, accompanied by enhanced inducible nitric oxide synthase expression.