Cytofluorimetric and reverse-transcription polymerase chain reaction (RT-PCR) analysis showed that adriamycinresistant (ADR R ), but not sensitive (WT), MCF-7 human mammary carcinoma cell lines express a4b1 and a5b1 integrins. ADR R cells adhere to fibronectin (FN), and only a5b1 is involved in cell
✦ LIBER ✦
Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of α5β1 integrin in human breast carcinoma cells
✍ Scribed by Heng Wu; Yu-Long Liang; Zengxia Li; Jiawei Jin; Wen Zhang; Lingling Duan; Xiliang Zha
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 496 KB
- Volume
- 132
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Tumor cell expression of COX‐2 has been implicated in the progression of murine and human lung cancer. Inhibition of COX‐2 by nonsteroidal antiinflammatory drugs reduces the risk of cancer development in humans and suppresses tumor growth in animal models. However, the underlying mechan