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Positive Epstein–Barr virus and cytomegalovirus IgM assays in primary HIV infection

✍ Scribed by Jeffrey J. Post; Mun Khin Chan; L. Ross Whybin; Qin Shi; William D. Rawlinson; Philip Cunningham; Peter W. Robertson

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
162 KB
Volume
83
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

We report three cases with misleading cytomegalovirus (CMV) or Epstein–Barr virus (EBV) immunoglobulin M (IgM) results during primary human immunodeficiency virus (HIV) infection. We determined the rate of positive anti‐CMV IgM assays or anti‐EBV capsid antigen IgM assays in sera from a group of well‐characterized subjects with primary HIV infection as 2.9% (1/35; 95%CI: 0.15–16.6%) for each infection. The rate of positive anti‐EBV capsid antigen IgM assays in subjects with positive hepatitis A virus IgM assays was 30% (6/20; 95%CI: 14.6–51.9%). Clinicians need to consider the limitations of IgM assays for diagnosis of herpesvirus infections, and consider testing for other infections with overlapping clinical manifestations. J. Med. Virol. 83:1406–1409, 2011. © 2011 Wiley‐Liss, Inc.

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