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Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

✍ Scribed by Shusuke Numata; Shu-ichi Ueno; Jun-ichi Iga; Hongwei Song; Masahito Nakataki; Shin’Ya Tayoshi; Satsuki Sumitani; Masahito Tomotake; Mitsuo Itakura; Akira Sano; Tetsuro Ohmori


Book ID
113750376
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
403 KB
Volume
43
Category
Article
ISSN
0022-3956

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Gene expression and association analyses
✍ Shusuke Numata; Jun-ichi Iga; Masahito Nakataki; Shin'Ya Tayoshi; Kyoko Taniguch 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

## Abstract The phosphodiesterase 4B (PDE4B) interacts with disrupted‐in‐schizophrenia 1 (DISC1), which is a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). PDE4B is also important in the regulation of cAMP signaling, a second messenger implicated