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Positive and negative signaling components involved in TNFα-induced NF-κB activation

✍ Scribed by Hongxiu Li; Xin Lin

Book ID: 116398106
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 380 KB
Volume: 41
Category: Article
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2007.09.016

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## Abstract The pleiotropic cytokine tumor necrosis factor alpha (TNF‐α) can induce apoptosis but also supports cell survival pathways. Among the possible anti‐apoptotic mechanisms of TNF‐α is the activation of the transcription factor NF‐κB. Since reactive oxygen species (ROS) are assumed to contr