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Positive and negative regulators of transforming growth factor beta 1/bone morphogenetic protein pathways are constitutively expressed in mesangial cells

✍ Scribed by TT Maciel,N Schor,AH Campos


Book ID
126387113
Publisher
Springer (Biomed Central Ltd.)
Year
2003
Tongue
English
Weight
507 KB
Volume
7
Category
Article
ISSN
1466-609X

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## Abstract ## Objective Bone morphogenetic protein (BMP) and transforming growth factor Ξ² (TGFΞ²) are potent anabolic factors in adult articular chondrocytes. In this study, we investigated whether intracellular inhibitors of BMP and TGFΞ² signaling, inhibitory Smad6 (I‐Smad6) and I‐Smad7, are expr