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Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques

✍ Scribed by Claire E Shepherd; Gillian C Gregory; James C Vickers; William S Brooks; John B.J Kwok; Peter R Schofield; Jillian J Kril; Glenda M Halliday


Book ID
116761527
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
270 KB
Volume
15
Category
Article
ISSN
0969-9961

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Effects of cyclin-dependent kinase-5 act
✍ Shirley B. Shelton; Pavan Krishnamurthy; Gail V.W. Johnson πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 392 KB

## Abstract Cyclin‐dependent kinase‐5 (CDK5), a unique CDK family member, is active primarily in the central nervous system (CNS). Previous studies suggest that CDK5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in Alzheimer's disease. The objective of this study