Positional cues that are strictly localized in the telencephalon induce preferential growth of mitral cell axons
✍ Scribed by Sugisaki, Nobuyuki ;Hirata, Tatsumi ;Naruse, Ichiro ;Kawakami, Atsushi ;Kitsukawa, Takashi ;Fujisawa, Hajime
- Book ID
- 102655463
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 1007 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
In mice, mitral cells are the major efferent neurons of the main olfactory bulb and elongate axons into a very narrow part of the telencephalon to form a fiber bundle referred to as the lateral olfactory tract (LOT). To clarify the mechanisms responsible for guidance of mitral cell axons along this particular pathway, we co-cultured mouse embryo main olfactory bulbs with the telencepha-Ions, and analyzed the pathways taken by mitral cell axons. Ingrowth of mitral cell axons into the telencephalon was observed in those co-cultures in which the olfactory bulbs had been exactly combined to their normal pathway (the LOT position) of the telencephalon. The axons grew preferentially along the L O T position, and formed a LOT-like fiber bundle. When the olfactory bulbs were grafted a t positions apart from their normal pathway, however, no mitral cell axons grew into the telencepha-Ion. Neocortical fragments combined with the telencephalon projected fibers into the telencephalon in random directions. These results suggest that the LOT position of the telencephalon offers a guiding pathway for mitral cell axons and that guiding cues for mitral cell axons are extremely localized.