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Positional Cloning of the nude Locus: Genetic, Physical, and Transcription Maps of the Region and Mutations in the Mouse and Rat

✍ Scribed by Julia A. Segre; Jennifer L. Nemhauser; Benjamin A. Taylor; Joseph H. Nadeau; Eric S. Lander


Book ID
115612749
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
792 KB
Volume
28
Category
Article
ISSN
0888-7543

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The nude trait in the rat is transmitted in an autosomal recessive manner and is associated with thymic aplasia, T-cell deficiency, and hairlessness. Congenic rats homozygous for the R N U (Rowett nude) locus are important models in the study of inflammatory disease, tumor growth, and transplant rej