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Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21

✍ Scribed by Meza-Zepeda, Leonardo A; Forus, Anne; Lygren, Birgitte; Dahlberg, Anine B; Godager, Linda H; South, Andrew P; Marenholz, Ingo; Lioumi, Maria; Flørenes, Vivi Ann; Mælandsmo, Gunhild M

Book ID
110066540
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
798 KB
Volume
21
Category
Article
ISSN
0950-9232

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Amplification of 1q21 is the most frequent genetic alteration in human hepatocellular carcinoma (HCC), being detected in 58%-78% of primary HCC cases by comparative genomic hybridization. Recently, we isolated a candidate oncogene, Amplified in Liver Cancer 1 (ALC1), from 1q21 by hybrid selection. H