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Position-independent, aberrant expression of the human ornithine decarboxylase gene in transgenic mice

✍ Scribed by Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; Olli A. Janne; Juhani Jänne

Book ID
117055496
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
425 KB
Volume
180
Category
Article
ISSN
0006-291X

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Induced expression of neurotrophins in t
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine
✍ M. Reeben; J. Arbatova; J. Palgi; R. Miettinen; M. Halmekytö; L. Alhonen; J. Jän 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 749 KB

Transgenic mice overexpressing ornithine decarboxylase (ODC) were recently generated (Halmekyto et al.: Biochem Biophys Res Commun 180:262-267, 1991). The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. As elevated polyamine levels in the br