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Porphyria cutanea tarda in the HFE-gene and hepatitis C virus era

✍ Scribed by Guy Vautier; John K Olynyk

Book ID
119390087
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
33 KB
Volume
95
Category
Article
ISSN
0002-9270

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In some, but not all countries, porphyria cutanea tarda (PCT) has been associated with chronic infection with the hepatitis C virus (HCV). Recently, PCT has also been associated with mutations in the HFE gene that are associated with HLA-linked hereditary hemochromatosis. Until now, few studies of t

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We studied the prevalence of hepatitis C virus (HCV) infection in 20 Japanese patients with sporadic-type porphyria cutanea tarda (PCT). Seventeen of the 20 patients (85%) had anti-HCV antibodies. Biochemical remission was observed in nine patients, six of whom still had positive HCV RNA copies. The