Porous silk scaffolds can be used for tissue engineering annulus fibrosus
β Scribed by G. Chang; H.-J. Kim; D. Kaplan; G. Vunjak-Novakovic; R. A. Kandel
- Book ID
- 106190948
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 434 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0940-6719
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## Abstract There is presently no optimal treatment for patients with chronic back pain as a result of degenerative disc disease. Tissue engineering, an annulus fibrosus (AF) construct suitable to repair the damaged AF, is one novel approach to the treatment of this disease. We have previously demo
## Abstract The annulus fibrosus comprises concentric lamellae that can be damaged due to intervertebral disc degeneration; to provide permanent repair of these acquired structural defects, one solution is to fabricate scaffolds that are designed to support the growth of annulus fibrosus cells. In
## Abstract Engineering a functional replacement for the annulus fibrosus (AF) of the intervertebral disc is contingent upon recapitulation of AF structure, composition, and mechanical properties. In this study, we propose a new paradigm for AF tissue engineering that focuses on the reconstitution