Pore-Forming Toxins Trigger Shedding of Receptors for Interleukin 6 and Lipopolysaccharide

Design, Synthesis, and Pharmacological C

Design, Synthesis, and Pharmacological Characterization of Polyamine Toxin Derivatives: Potent Ligands for the Pore-Forming Region of AMPA Receptors

✍ Lars S. Jensen; Ulrik Bølcho; Jan Egebjerg; Kristian Strømgaard 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB

## Abstract Polyamine toxins, such as philanthotoxins, are low‐molecular‐weight compounds isolated from spiders and wasps, which modulate ligand‐gated ion channels in the nervous system. Philanthotoxins bind to the pore‐forming region of AMPA receptors, a subtype of glutamate receptors which are im