✦ LIBER ✦

Porcine gelatin microsphere/calcium phosphate cement composites: An in vitro degradation study

✍ Scribed by Wouter J. E. M. Habraken; Joop G. C. Wolke; Antonios G. Mikos; John A. Jansen

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 377 KB
Volume: 91B
Category: Article
ISSN: 1552-4973
DOI: 10.1002/jbm.b.31429

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✦ Synopsis

Abstract

Scaffolds for bone tissue engineering preferably should be mechanically stable, osteoconductive, biodegradable and porous. To comply with these characteristics, calcium phosphate cements (CPCs) with porcine (type A) gelatin microspheres were formulated. In this experiment, in vitro degradation of 10 wt % gelatin type A microsphere CPCs (GELA CPCs) was followed for 12 weeks in proteolytic medium. Results showed a gradual decrease in mass, compression strength and E‐modulus. Morphology investigation showed that degradation of the spheres started at the surface of the composite and gradually proceeded to the inner part. Overall, porcine gelatin microspheres can be used to generate in situ macroporosity into an injectable CPC. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009

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