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Population pharmacokinetics of melphalan, infused over a 24-hour period, in patients with advanced malignancies

✍ Scribed by Philippe Mougenot; Frédéric Pinguet; Michel Fabbro; Stéphane Culine; Sylvain Poujol; Cécile Astre; Françoise Bressolle


Book ID
105991922
Publisher
Springer
Year
2004
Tongue
English
Weight
359 KB
Volume
53
Category
Article
ISSN
0344-5704

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## BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly