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Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults

โœ Scribed by Divya Menon-Andersen; John T. Mondick; Bhuvana Jayaraman; Patrick A. Thompson; Susan M. Blaney; Mark Bernstein; Mason Bond; Martin Champagne; Michael J. Fossler; Jeffrey S. Barrett

Publisher
Springer
Year
2008
Tongue
English
Weight
873 KB
Volume
63
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND Highโ€dose methotrexate (HDMTX) is used frequently in combination regimens that include nephrotoxic chemotherapy. The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and