Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting
✍ Scribed by Susumu Nakade; Tomoya Ohno; Junsaku Kitagawa; Yoshitaka Hashimoto; Masahiro Katayama; Hiroshi Awata; Yasuo Kodama; Yasuyuki Miyata
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 509 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND The neurokinin‐1 antagonist aprepitant (EMEND™; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy‐induced nausea and vomiting when it is given with a 5‐hydroxytryptamine‐3 receptor antagonist and dexamethasone. The current study sought to
## Abstract ## BACKGROUND. The combination of palonosetron and aprepitant is safe and effective in the prevention of chemotherapy‐induced emesis (CIE). The purpose of this pilot study was to ascertain the effectiveness of 1‐day versus 3‐day aprepitant in the prevention of acute and delayed nausea