Timed-release formulation to avoid drugโ
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Toyohiro Sawada; Kazuhiro Sako; Keiichi Yoshihara; Katsutoshi Nakamura; Shigehar
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Article
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2003
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John Wiley and Sons
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English
โ 107 KB
The purpose of this study was to investigate whether the use of a timed-release (TR) drug formulation can avoid unfavorable pharmacokinetic drug-drug interactions in vivo. First, the effects of the time interval between administration of midazolam and diltiazem on the known drug-drug interaction bet