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Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients

โœ Scribed by Jane E Latz; Ajai Chaudhary; Atalanta Ghosh; Robert D Johnson

Publisher
Springer
Year
2005
Tongue
English
Weight
419 KB
Volume
57
Category
Article
ISSN
0344-5704

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Many popular sequential phase II clinical trial designs optimize some criterion subject to constraints on the error probabilities at null and alternative values of the response rate. Such designs may forfeit optimality if one fails to conduct analyses strictly according to plan. Moreover, a decision