Population choice in mapping genes for complex diseases
β Scribed by Wright, Alan F; Carothers, Andrew D; Pirastu, Mario
- Book ID
- 109827132
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 141 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/70501
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Linkage disequilibrium (LD) or association studies using caseβparent trios have become a common approach to locate unobserved susceptibility genes underlying complex diseases. With the availability of ever more dense marker maps, how to utilize the information carried by multiple marker
## Abstract Models for complex and quantitative traits that involve multiple, possibly interacting, genes are described. Methods of linkage analysis are developed that utilize special features of these models, and their power is compared with that of simple genome scans that ignore these special fe
## Abstract Nature determines the complexity of disease etiology and the likelihood of revealing disease genes. While culprit genes for many monogenic diseases have been successfully unraveled, efforts to map major complex disease genes have not been as productive as hoped. The conceptual framework