Population-based case control study of folic acid supplementation during pregnancy

✍ Scribed by Czeizel, Andrew E.; Tóth, Márta; Rockenbauer, Magda

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 743 KB
• Volume: 53
• Category: Article
• ISSN: 0040-3709
• DOI: 10.1002/(sici)1096-9926(199606)53:6<345::aid-tera5>3.0.co;2-z

✦ Synopsis

Previous studies have demonstrated that periconceptional folic acid/multivitamin supplementation reduced the occurrence of neural tube defects. A case control analysis has been conducted in the dataset of the Hungarian Case Control Surveillance of Congenital Abnormalities, 1980-1 991. In the study period, 54.9% of 30 663 pregnant women who had healthy babies (negative control group) were supplemented with high doses (in general 2 x 3 mg) of folic acid per day. In those 17,300 pregnant women who had offspring with congenital abnormalities, the rate of folic acid supplementation was 50.4%. Exposure histories: preconceptional, I, 11, 111, and IV-IX postconceptional months were determined by record reviews and questionnaire assessment. The case control pair analysis showed a significant protection after folic acid supplementation during the critical period of cardiovascular defects, neural tube defects, cleft lip with or without cleft palate and posterior cleft palate. 0 1996 Wiley-Liss, Inc.