Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder

✍ Scribed by Stephanie M. Groman; Alex S. James; J. David Jentsch

• Book ID: 104065084
• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 326 KB
• Volume: 33
• Category: Article
• ISSN: 0149-7634
• DOI: 10.1016/j.neubiorev.2008.08.008

✦ Synopsis

As the evidence for the genetic influences on risk for major mental disorders becomes increasingly clear, the search for quantitative trait indicators of specific risk-associated alleles is underway. The sought-after traits are often conceptualized as behavioral, cognitive or biological phenotypes that are ''simpler'' than multi-dimensional psychiatric disorders and that are, consequently, determined by a simpler set of genetic mechanisms than is the complex disorder phenotype. As a result, these traits are potentially more fruitful candidates for gene discovery efforts (Bearden and Freimer, 2006;Gottesman and Gould, 2003). In addition, these ''endophenotypes'' would ideally be reliable indicators of the brain dysfunction that represents risk for the