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Pool size of CDP-choline in the brain, heart, and lung of normal and hypoxic guinea pigs

✍ Scribed by Dr. M. Alberghina; M. Viola; A. M. Giuffrida

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
259 KB
Volume
6
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The pool size of CDP‐choline in the brain, heart, and lung of normal and hypoxic animals was measured by radioactive isotopic dilution. The effect of exogenous CDP‐choline administration on the pool size in these experimental groups was also examined. The hypoxic treatment caused a significant decrease of endogenous CDP‐choline in the brain and lung only; no significant effect was observed in the examined organs after CDP‐choline treatment.

📜 SIMILAR VOLUMES

Effect of CDP-choline on the biosynthesi
Effect of CDP-choline on the biosynthesis of phospholipids in brain regions during hypoxic treatment
✍ Dr. M. Alberghina; M. Viola; I. Serra; A. Mistretta; A. M. Giuffrida 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 780 KB

## Abstract Acute administration of CDP‐choline (i.p. 100 mg/Kg b.w.), 10 min before the intraventricular injection of labeled precursors, [2‐^3^H]glycerol and [1‐^14^C]‐palmitate, was able to correct the impairment caused by hypoxic treatment of lipid metabolism in some brain regions, ie, cerebral