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Polyvinylsulfonic Acid: An Efficient, Water-Soluble and Reusable Brønsted Acid Catalyst for the Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones in Water and Ethanol

✍ Scribed by Ali Rahmatpour

Book ID
118797465
Publisher
Springer US
Year
2012
Tongue
English
Weight
262 KB
Volume
142
Category
Article
ISSN
1011-372X

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Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a b-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without