✦ LIBER ✦

Polyurethanes as Carriers of Antitumorous Drugs

✍ Scribed by Rinat Iskakov; Erkesh Batyrbekov; Bulat Zhubanov; Tynyskul Teleuova; Marina Volkova

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 265 KB
Volume: 9
Category: Article
ISSN: 1042-7147
DOI: 10.1002/(sici)1099-1581(199804)9:4<266::aid-pat752>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Drug delivery systems on a polyurethane base with various antitumorous drugs, such as cyclophosphane, thiophosphamide and vincristine, have been prepared. An in vitro technique was used to determine the release characteristics of the drugs into model biological media. It was shown the drug release occurs in accordance with first-order kinetics, as well a maximum degree for the drug loading were studied. The thermodynamic parameters of drug release has been determined. It was illustrated that the activation energies were 4.3, 3.9 and 3.2 kcal/mole for cyclophosphane, thiophosphamide and vincristine respectively, corresponding to a diffusecontrolled mechanism of release.

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