Gene amplification or structural alteration of different erbB genes exerts a transforming effect in a variety of human neoplasms. Overexpression of the EGF receptor is associated with tumor initiation and progression of renal cell carcinoma (RCC). However, the role of erbB-2 in these processes remai
Polysomy of chromosome 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines
β Scribed by W. Henn; N. Blin; K. D. Zang
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 231 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-6717
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## Abstract It has been previously demonstrated that human carcinomas express interleukinβ2 receptor (ILβ2R) Ξ±, Ξ², and Ξ³ chains. The Ξ² and Ξ³ chains of ILβ2R have intermediate binding affinity for ILβ2 and are responsible for the intracellular signaling cascades after ILβ2 stimulation. ILβ2RΞ± lacks