Polysomnographic record and successful management of augmentation in restless legs syndrome/Willis–Ekbom disease
✍ Scribed by Maestri, Michelangelo; Fulda, Stephany; Ferini-Strambi, Luigi; Zucconi, Marco; Marelli, Sara; Staedler, Claudio; Bassetti, Claudio L.; Manconi, Mauro
- Book ID
- 124138794
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 450 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1389-9457
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## Abstract Augmentation, defined as a loss of circadian recurrence with progressively earlier daily onset and increase in the duration, intensity, and anatomy of symptoms, not compatible with the half‐life of the drug, is associated with dopaminergic treatment in restless legs syndrome (RLS) patie
## Abstract The purpose of this study was to evaluate the incidence of augmentation over 66 weeks of treatment with ropinirole in patients with primary restless legs syndrome (RLS). Augmentation is the main complication of long‐term dopaminergic treatment of RLS. Despite widespread use of ropinirol