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Polysiloxanes as matrix materials for slow release of 2-pyridine aldoxime chloride

✍ Scribed by Gupta, Dinesh C.; Sumana, Gajjala; Agarwal, Seema

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 241 KB
Volume: 45
Category: Article
ISSN: 0959-8103
DOI: 10.1002/(sici)1097-0126(199802)45:2<211::aid-pi901>3.0.co;2-f

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✦ Synopsis

The efficacy of polysiloxanes and copolysiloxanes as matrix materials for the slow release of 2-pyridine aldoxime chloride (2-PAM-Cl) was investigated by in vitro studies using both slabs and microcapsules. The release rate of 2-PAM-Cl was determined in pH 7É4 phosphate bu †er at 37¡C. Transport parameters such as the Fickian coefficient, di †usion coefficient, and the polymerÈ 2-PAM-Cl interaction parameter were calculated. The order of release and the time taken for 80% release were also calculated.

1998 SCI.

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