Polypeptide nanocoatings for preventing dental and orthopaedic device-associated infection: pH-induced antibiotic capture, release, and antibiotic efficacy
✍ Scribed by Bingbing Jiang; Bingyun Li
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 335 KB
- Volume
- 88B
- Category
- Article
- ISSN
- 1552-4973
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✦ Synopsis
Abstract
Implant‐associated infection is one of the most common and problematic complications for dental and orthopaedic patients. Modification of currently used implant surfaces aimed at bestowing them with antibacterial properties is a promising approach in the development of new biomaterials. In this study, a novel nanotechnology, that is, electrostatic self‐assembly, was developed to construct biomimetic polypeptide nanocoatings on commonly used metal implants. A model antibacterial drug, cefazolin, was captured in the polypeptide nanocoating and its release was studied. We have shown that the capture and release of cefazolin was pH‐induced and could be controlled, and the developed antibiotic‐incorporated polypeptide multilayer nanocoatings could prevent Staphylococcus aureus colonization thus showing great potential for preventing implant‐associated infection. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009