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Polyoxyethylene-coated nanospheres: effect of coating on zeta potential and phagocytosis

✍ Scribed by Gref, Ruxandra; Miralles, Grégory; Dellacherie, Édith

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
197 KB
Volume
48
Category
Article
ISSN
0959-8103

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✦ Synopsis

Polylactic acid (PLA) nanospheres coated with monomethoxypolyoxyethylene (MPOE) were prepared from amphiphilic diblock copolymers (MPOE-PLA) by an emulsion-evaporation procedure in the presence of sodium cholate as surfactant. Nanospheres with various concentrations of MPOE at their surface and various MPOE molar masses were obtained by using blends of PLA with diþ erent MPOE-PLA. The surface properties of these nanospheres were analysed, ürstly by measuring the particle zeta potential and secondly by studying their phagocytosis by monocytes. It was found that the increase in MPOE concentration and molar mass provoked a disappearance of the negative charge at the surface together with a decrease in the extent of phagocytosis. It is concluded that the brush of MPOE at the particle surface masks the PLA carboxylate end-groups, lowers the PLA hydrophobic character and, above all, hampers the approach of the proteins responsible for phagocytosis.

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