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Polymorphisms of the NER pathway genes,ERCC1andXPDare associated with esophageal adenocarcinoma risk

✍ Scribed by Darren Tse; Rihong Zhai; Wei Zhou; Rebecca S. Heist; Kofi Asomaning; Li Su; Thomas J. Lynch; John C. Wain; David C. Christiani; Geoffrey Liu

Book ID
106382687
Publisher
Springer Netherlands
Year
2008
Tongue
English
Weight
186 KB
Volume
19
Category
Article
ISSN
0957-5243

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## Abstract Rates of adenocarcinoma of the esophagus (EAC) and esophago‐gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro‐esophageal acid reflux and smoking, are potentially genotoxic through the generation of __N__‐nitroso compounds. The DNA repair