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Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients

✍ Scribed by Hak-Jae Kim; Kyung-Hwan Jeong; Sang-Ho Lee; Joo-Young Moon; Tae-won Lee; Sun Woo Kang; Suk Joo Park; Yeong-Hoon Kim; Joo-Ho Chung

Book ID
116940309
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
154 KB
Volume
24
Category
Article
ISSN
0966-3274

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✍ James D. Perkins πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 80 KB

Background: The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene encodes for a membrane bound (mCTLA-4) and a soluble sCTLA-4 isoform, which are both involved in regulation of T cell function. The CTLA-4 Ο©49A/G single nucleotide polymorphism (SNP) influences expression of mCTLA-4; Ο©6230G/A SNP affects