Polymorphisms of TAP 1 and TAP2 genes in Graves' disease
✍ Scribed by H. Rau; A. Nicolay; K. H. Usadel; R. Finke; H. Donner; P. G. Walfish; K. Badenhoop
- Book ID
- 110890589
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 569 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0001-2815
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A total of 95 patients with active Graves' disease (GD) and 105 normal healthy subjects were enrolled in this study, which attempted to determine whether single-site polymorphisms of the transporter associated with antigen processing 2 (TAP2) gene contribute to an individual's susceptibility to GD.
Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into