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Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases

✍ Scribed by Beena Mailaparambil; Johannes Jochum; Johannes Forster; Jessica Heinze; Marcus Krueger; Andrea Heinzmann


Publisher
Springer Vienna
Year
2008
Tongue
English
Weight
177 KB
Volume
153
Category
Article
ISSN
1432-8798

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Functional polymorphism of the promoter
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Prostaglandin I 2 (PGI 2 ) protects against RSVinduced illness in mice. A variable-number tandem repeat (VNTR) polymorphism has been detected in the promoter region of the PGI 2 synthase (PGIS) gene. We sought to determine if PGI 2 concentrations or polymorphisms of the PGIS gene correlate with seve