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Polymorphisms of FAS and FAS ligand genes and risk of skin cancer

✍ Scribed by Qureshi, Abrar; Nan, Hongmei; Dyer, Michael; Han, Jiali

Book ID: 119293574
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 92 KB
Volume: 58
Category: Article
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2010.01.003

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## Abstract The FAS receptor/ligand system is a key regulator of apoptotic cell death and corruption of this signaling pathway has been shown to participate in carcinogenesis. Functional polymorphisms in the FAS (FAS −1377G/A) and FASL (FASL −844T/C) genes alter their transcriptional activity. Ther