Alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5'-flanking region of P450IIEI. In this study, we used
Polymorphisms of alcohol metabolizing enzyme and cytochrome P4502E1 genes in mongolian population
β Scribed by Ki-Woong Kim; Bayanbileg Shinetugs; Kyung-Hwa Heo; Yong Lim Won; Tserenkhuu Lkhagwasuren; Sung Keun Chang; Sang-Gi Paik
- Publisher
- The Genetics Society of Korea
- Year
- 2009
- Tongue
- English
- Weight
- 154 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1976-9571
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The human cytochrome P4502El gene (P4502E1), coding for an ethanol-inducible nitrosamine-metabolizing P-450, is involved in the metabolism of ethanol and many known carcinogens. Recently, restriction fragment length polymorphisms (RFLps) within the P4502E1 have been suggested as genetic markers of s
## Abstract ## BACKGROUND. It is believed that acetaldehyde plays an important role in alcoholβrelated carcinogenesis; although current epidemiologic studies have provided inconsistent findings on the association between alcohol consumption and the risk of lung cancer. ## METHODS. To clarify the