Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection

Induction of interferon-λ contributes to

Induction of interferon-λ contributes to toll-like receptor 3-mediated herpes simplex virus type 1 inhibition in astrocytes

✍ Jieliang Li; Li Ye; Xu Wang; Shuxian Hu; Wenzhe Ho 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 625 KB

## Abstract Toll‐like receptor 3 (TLR3) recognizes double‐stranded RNA and induces type I interferon (IFN)‐mediated antiviral immunity against a number of viral infections. Type III IFN (IFN‐λ) is a newly identified antiviral cytokine that has biological functions similar to those of type I IFNs. W