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Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population

✍ Scribed by Hongxia Ma; Zhibin Hu; Xiangjun Zhai; Shui Wang; Xuechen Wang; Jianwei Qin; Guangfu Jin; Jiyong Liu; Xinru Wang; Qingyi Wei; Hongbing Shen

Book ID
116333983
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
149 KB
Volume
240
Category
Article
ISSN
0304-3835

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## Abstract Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/