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Polymorphisms in the interleukin-4 receptor α chain gene influence susceptibility to HIV-1 infection and its progression to AIDS

✍ Scribed by Alex Soriano; Francisco Lozano; Harold Oliva; Felipe García; Meritxell Nomdedéu; Elisa De Lazzari; Carmen Rodríguez; Alicia Barrasa; José I. Lorenzo; Jorge del Romero; Montserrat Plana; José M. Miró; José M. Gatell; Jordi Vives; Teresa Gallart

Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
221 KB
Volume
57
Category
Article
ISSN
0093-7711

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## Abstract The clinical course and outcome of HIV‐1 infection are highly variable among individuals. Interleukin 4 (IL‐4) is a key T helper 2 cytokine with various immune‐modulating functions including induction of immunoglobulin E (IgE) production in B cells, downregulation of CCR5 and upregulati