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Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer- ITGB4 as prognostic marker

✍ Scribed by A. Brendle; H. Lei; A. Brandt; R. Johansson; K. Enquist; R. Henriksson; K. Hemminki; P. Lenner; A. Försti

Book ID
119598567
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
98 KB
Volume
6
Category
Article
ISSN
1359-6349

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✍ Tair Kontorovich; Asaf Levy; Michael Korostishevsky; Uri Nir; Eitan Friedman 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 530 KB

## Abstract We hypothesized that aberrant gene silencing by miRNA may affect mutant __BRCA__ penetrance. To test this notion, frequency of single nucleotide polymorphisms (SNPs; __n__ = 42) within predicted miRNA binding sites or miRNA precursors were determined and compared in 363 __BRCA1__ mutati