Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
✍ Scribed by Potočnik, U; Ferkolj, I; Glavač, D; Dean, M
- Book ID
- 110037636
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 228 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1466-4879
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Background: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug resistance gene (MDR)1 polymorphisms would be associated with CsA failure. ## Patients and Methods
The aim of this study is to determine whether the polymorphisms of the MDR1 gene are associated with the development of childhood acute lymphoblastic leukemia (ALL). The MDR1 gene polymorphisms, -2352 G>A, -934A>G, -692T>C (5' regulatory region) and 3435C>T (exon 26), were examined in 157 ALL patien