Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
β Scribed by Knapp, S; Yee, L J; Frodsham, A J; Hennig, B J W; Hellier, S; Zhang, L; Wright, M; Chiaramonte, M; Graves, M; Thomas, H C
- Book ID
- 110037505
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 121 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1466-4879
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Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with hum
## Abstract Cytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of inappropriate cytokine levels appears to contribute to viral persistence and to affect response to therapy. Cytokine genes are polymorphic at specific sites, and cert
biochemical and histological improvement. 3,4 Several factors Hepatitis C virus (HCV) genotype 1b and high precan predict a poor response to interferon therapy, e.g., high treatment virus load are predictive factors of poor repretreatment virus load, genotype 1b, advanced histological sponse to inte