Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer
β Scribed by Wade S. Samowitz; Roger K. Wolff; Khe Ni Ma; Kristen Andersen; Bette Caan; Martha L. Slattery
- Book ID
- 113808798
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 98 KB
- Volume
- 595
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Which carcinogens are of influence in the development of human colorectal cancers remains a question; one answer could be the finding that specific polymorphisms in xenobiotic metabolizing enzymes are related to particular mutations in cancer genes. __KRAS2__ and __TP53__ gene mutations
The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is a key negative regulator of the TP53 pathway and is overexpressed in many cancers as oncoprotein. We