Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease
โ Scribed by Lisa Gallicchio; Sonja I Berndt; Meghan A McSorley; Craig J Newschaffer; Lucy W Thuita; Pedram Argani; Sandra C Hoffman; Kathy J Helzlsouer
- Book ID
- 115010817
- Publisher
- BioMed Central
- Year
- 2006
- Tongue
- English
- Weight
- 292 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1471-2407
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๐ SIMILAR VOLUMES
## Abstract Estrogen and its metabolites are believed to play important roles in breast cancer, and its determinants include both genetic and lifestyle factors. The objective of the study is to investigate the association of breast cancer risk in Thailand with genetic polymorphisms in several genes
## Abstract Estrogens exert their effect on the breast through the estrogen receptor. We prospectively investigated breast cancer risk associated with 2 polymorphic sites in the estrogen receptor alpha gene (__ESR1__). A total of 4,248 Caucasian women from the Study of Osteoporotic Fractures were g